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Year : 2018  |  Volume : 6  |  Issue : 3  |  Page : 1-4

Comparison of systemic and topical forms of curcumin in oral submucous fibrosis: A clinical and histopathological evaluation in 120 patients

1 Oral Medicine and Radiology, Consultant Dental Practitioner, Ahmedabad, Gujarat, India
2 Orthodontics and Dentofacial Orthopedics, Consultant Orthodontist, Ahmedabad, Gujarat, India
3 Periodontology, Consultant Periodontist, Senior lecturer in College of Dental Science and Research Centre, Ahmedabad, Gujarat, India
4 Oral Pathology, Ahmedabad, Gujarat, India

Correspondence Address:
Dr. Nipa Chauhan
A/7 Parth society, Behind partheshwar temple, Isanpur, Ahmedabad, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/INJO.INJO_3_18

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Introduction: Oral submucous fibrosis (OMSF) is a chronic insidious disease of oral mucosa, which is considered as a premalignant condition but has high malignant potential of approximately 7%–30%. Many treatment modalities have been tried since years but none have proved to be curative. Turmeric has been attributed a number of medicinal properties. Turmeric and its active ingredient, “curcumin” are being studied as chemopreventive agents in India and abroad. This study was proposed to evaluate the efficacy of curcumin in patients with OSMF and compare it with conventional treatment such as multivitamin and antioxidant tablets. Materials and Methods: A total of 120 patients who were clinically and histopathologically confirmed as having OSMF were selected and randomly divided into four groups. Group I patients were given tablets, Group II were given capsules, Group III were given oil, and Group IV were given multivitamin tablets. Patients were recalled every 15 days for 8 weeks and results were analyzed using analysis of variance test. Results: After treatment and follow-up, a significant improvement was seen in patients treated with curcumin when compared to those in control group. Conclusion: Curcumin as a treatment modality is efficient, noninvasive, beneficial, and economic for the patients with OSMF.

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